Manchester United's FA Cup title defence came to an end at home to Fulham as Bernd Leno saved Victor Lindelof and Joshua Zirkzee's spot-kicks to send Marco Silva's men through to the quarter-finals on penalties.
The Red Devils reached the final in both seasons under Erik ten Hag, but Ruben Amorim's stumbling side saw their dreams extinguished in the fifth round on Sunday as the Whites reached the final eight for the second time in three campaigns.
Leno was Fulham's hero as the goalkeeper produced a pair of saves in a 4-3 shootout win after an end-to-end encounter finished 1-1 after extra-time, with a home quarter-final against Crystal Palace the reward.
Progress was particularly sweet given Silva was sent off along with Willian and Aleksandar Mitrovic during a minute of madness in a quarter-final collapse at Old Trafford two years ago.
Calvin Bassey's header in first-half stoppage-time gave Fulham the lead this time, only for Bruno Fernandes to delight frustrated United fans - and silence outspoken former skipper Roy Keane - with a great first-time equaliser.
Both sides had chances to win the fifth-round tie before it reached penalties, when Leno denied Lindelof and Zirkzee to seal a famous Old Trafford win.
Danny Welbeck came off the bench to fire Brighton into the quarter-finals at Newcastle as Anthony Gordon's Carabao Cup final dream was shattered by a late red card.
Welbeck, who scored the winner in the Premier League game at St James' Park in October, struck in extra-time to win it 2-1 on an afternoon when both sides finished with 10 men.
Gordon was sent off for violent conduct with six minutes of a chaotic tie remaining - Tariq Lamptey later suffered the same fate after collecting a second yellow card - and faces a three-match ban which will cost him his place in the team for the clash with Liverpool at Wembley on 16 March.
Alexander Isak's 22nd-minute penalty had given the hosts - who were without full-back Lewis Hall because of an ankle injury which will require a visit to a specialist - a lead which was cancelled out before half-time by former Magpie Yankuba Minteh, and an at times scruffy game remained in the balance until Welbeck's intervention.
FA Cup quarter-final draw:
Fulham v Crystal Palace
Preston v Aston Villa
Bournemouth v Manchester City
Brighton v Nottingham Forest or Ipswich
Ties to be played over the final weekend of March
