Julian Alvarez put Atletico Madrid back on top of La Liga as his side put away a wasteful Athletic Bilbao to seal a vital 1-0 win.
Alvarez slotted home a sharp finish after a neat assist from fellow substitute Marcos Llorente to settle the clash at the Riyadh Air Metropolitano and nudge his side two points above title rivals Real Madrid and Barcelona.
But Athletic will rue a glut of missed chances, including three attempts that hit the woodwork and at least two dreadful misses in fine positions as their 16-match unbeaten streak in the league came to an end.
Real had earlier succumbed 2-1 at Real Betis to undermine their own hopes of regaining top spot. Brahim Diaz put Carlo Ancelotti's side ahead in the 10th minute before Johnny Cardoso headed home from a corner to level the match.
A penalty early in the second half gave Betis a chance to win it and former Los Blancos forward Isco stepped up to convert.
The other two matches finished in draws, Girona and Celta Vigo locked at 2-2 and Dodi Lukebakio securing a 1-1 draw for Sevilla at Rayo Vallecano.
Substitute Philip Billing ensured the battle between Serie A's top two sides finished with honours even.
Leaders Inter looked like taking all three points from their trip to Napoli after Federico Dimarco's precision free-kick handed them the lead midway through the first half. However, the visitors levelled in the 87th minute when Billing converted from close range at the second attempt.
That keeps the gap at a single point in Inter's favour as they look to retain their title.
Third-placed Atalanta missed the chance to make inroads after they were held to a goalless draw at relegation battlers Venezia, while Florian Thauvin's penalty sealed a 1-0 win for Udinese against Parma.
Defending Bundesliga champions Bayer Leverkusen came through their visit to third-placed Eintracht Frankfurt with flying colours after a 4-1 away win. Nathan Tella, Nordi Mukiele, Patrick Schick and Aleix Garcia all hit the target, with Hugo Ekitike grabbing the consolation.
Borussia Dortmund recorded back-to-back league wins for the first time in a disappointing season, besting St Pauli 2-0 with goals from Serhou Guirassy and Karim Adeyimi.
Mainz were up to fourth after a hard-earned 2-1 win at RB Leipzig. The sides were level on points at the start of the day and Leipzig made a perfect start when Xavi Simons put them ahead after just a minute's play.
But that was as good as it got for the hosts, who saw Nadiem Amiri and Jonathan Burkardt reverse the result.
Patrick Wimmer scored both goals as Wolfsburg beat Werder Bremen 2-1, Tom Bischof claimed a 1-0 win for Hoffenheim at Bochum and strugglers Heidenheim slumped to a 3-0 defeat by Borussia Monchengladbach.
Paris St Germain's domination of Ligue 1 continued as a 4-1 win over Lille made it nine in a row and left them 16 points clear.
Bradley Barcola, Ousmane Dembele, Desire Doue and Marquinhos all scored inside 37 minutes to end the game as a contest, though the only subsequent strike fell to Lille's Jonathan David.
Nice moved level on points alongside second-placed Marseille courtesy of a 3-1 away win at Saint-Etienne.
The sides were level at 1-1 half-time, but an own goal from Mickael Nade and another from Evann Guessand won it for the for Nice.
Struggling Le Havre fought hard for a dramatic 4-3 win at Lens, finishing a rousing comeback with an stoppage-time winner from the penalty spot.
The hosts were 2-0 and 3-2 in front, but could not hang on to the result, eventually giving away all three points when Ahmed Hassan held his nerve from 12 yards in added time.
