Holders Manchester United have been drawn to play Leicester at Old Trafford in the fourth round of the FA Cup.
United, who defeated Manchester City in last season's final, have been rewarded with a home tie after their 10 men won at Arsenal on penalties in the third round earlier on Sunday evening.
Premier League leaders Liverpool will travel to the Sky Bet Championship’s bottom club Plymouth, who upset Brentford on Saturday, and Pep Guardiola’s City face an away trip to either Leyton Orient or Derby.
Three all-Premier League ties will see eight-time winners Chelsea take on Brighton at the Amex Stadium, while Aston Villa host Tottenham and Everton face Bournemouth at Goodison Park.
Exeter, in the fourth round for the first time since 1981, face a tough home tie against Nottingham Forest and Newcastle will play at League One leaders Birmingham.
FA Cup draw:
Southampton v Burnley
Leyton Orient v Derby v Manchester City
Doncaster Rovers v Crystal Palace
Stoke City v Cardiff City
Birmingham City v Newcastle United
Plymouth Argyle v Liverpool
Everton v Bournemouth
Aston Villa v Tottenham Hotspur
Exeter City v Nottingham Forest
Coventry City v Ipswich Town
Blackburn Rovers v Wolves
Mansfield / Wigan v Fulham
Manchester United v Leicester City
Leeds United v Millwall / Dagenham & Redbridge
Brighton v Chelsea
Preston North End / Charlton v Wycome Wanderers
